Make your art the same size as they will be in game. So, if your actor is 32X32, make your art 32X32. If you're using resolution, just make your art double the size it will be in game. So if your actor is 32X32, make your art 64X64. There are other threads on this forum about optimizing art, but it'll go a long ways if you just keep your art the minimum size it needs to be.
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